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NCBI homepage Show account info Retinol and its derivative, retinoic acid, have pleiotropic functions including vision, immunity, hematopoiesis, reproduction, cell differentiation/growth, and development. Non-alcoholic fatty liver disease (NAFLD) is one of the most common diseases in developed countries and encompasses a broad spectrum of forms, ranging from steatosis to steatohepatitis, which develops further to cirrhosis. Retinol status has an important role in liver homeostasis. The purpose of this study was to evaluate the retinol status and expression of retinol-related proteins, including enzymes and binding proteins, in methionine-choline deficient (MCD) rats as a model of NAFLD. We examined retinol levels in the plasma and liver and gene expression for β-carotene 15,15'-monooxygenase (BCMO), lecithIn: retinol acyltransferase (LRAT), aldehyde dehydrogenase 1A1 (ALDH1A1), ALDH1A2, and cellular retinol binding protein (CRBP)-I in MCD rats. The plasma retinol levels in MCD rats were lower than those in the controls, whereas hepatic retinol levels in MCD rats were higher. BCMO expression in the intestine and liver in MCD rats was lower, whereas that in the testes and the kidneys was higher than in control rats. Expression of LRAT, CRBP-I, ALDH1A1, and ALDH1A2 in the liver of MCD rats was also higher. Altered expression of retinol-related proteins may affect retinol status in NAFLD. Takitani K, Kishi K, Miyazaki H, Koh M, Tamaki H, Inoue A, Tamai H. Takitani K, et al. Int J Mol Sci. 2018 Oct 26;19(11):3337. doi: 10.3390/ijms19113337. Int J Mol Sci. 2018. PMID: 30373117 Free PMC article. Takitani K, Miyazaki H, Fukunishi S, Takaya R, Yoden A, Higuchi K, Tamai H. Takitani K, et al. J Nutr Sci Vitaminol (Tokyo). 2011;57(1):108-13. doi: 10.3177/jnsv.57.108. J Nutr Sci Vitaminol (Tokyo). 2011. PMID: 21512299 Takitani K, Miyazaki H, Koh M, Kishi K, Inoue A, Tamai H. Takitani K, et al. J Nutr Sci Vitaminol (Tokyo). 2016;62(1):12-8. doi: 10.3177/jnsv.62.12. J Nutr Sci Vitaminol (Tokyo). 2016. PMID: 27117846 Saeed A, Dullaart RPF, Schreuder TCMA, Blokzijl H, Faber KN. Saeed A, et al. Nutrients. 2017 Dec 29;10(1):29. doi: 10.3390/nu10010029. Nutrients. 2017. PMID: 29286303 Free PMC article. Review. Ross AC, Zolfaghari R. Ross AC, et al. J Nutr. 2004 Jan;134(1):269S-275S. doi: 10.1093/jn/134.1.269S. J Nutr. 2004. PMID: 14704332 Review. Takitani K, Kishi K, Miyazaki H, Koh M, Tamaki H, Inoue A, Tamai H. Takitani K, et al. Int J Mol Sci. 2018 Oct 26;19(11):3337. doi: 10.3390/ijms19113337. Int J Mol Sci. 2018. PMID: 30373117 Free PMC article. Dong S, Cai FF, Chen QL, Song YN, Sun Y, Wei B, Li XY, Hu YY, Liu P, Su SB. Dong S, et al. Acta Pharmacol Sin. 2018 Jun;39(6):930-941. doi: 10.1038/aps.2017.150. Epub 2017 Nov 2. Acta Pharmacol Sin. 2018. PMID: 29094729 Free PMC article. Zhang Y, Meng T, Zuo L, Bei Y, Zhang Q, Su Z, Huang Y, Pang J, Xiang Q, Yang H. Zhang Y, et al. Mar Drugs. 2017 Jun 3;15(6):163. doi: 10.3390/md15060163. Mar Drugs. 2017. PMID: 28587208 Free PMC article. Takitani K, Inoue K, Koh M, Miyazaki H, Inoue A, Kishi K, Tamai H. Takitani K, et al. J Clin Biochem Nutr. 2015 May;56(3):195-200. doi: 10.3164/jcbn.14-113. Epub 2015 Jan 28. J Clin Biochem Nutr. 2015. PMID: 26060349 Free PMC article.